(S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Base Information

Chemical Name:(S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione
CAS No.:1370248-44-4
Molecular Formula:C₃₁H₂₉BrN₂O₄
Molecular Weight:573.486
Hs Code.:

Synonyms:(S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

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Chemical Property of (S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

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Technology Process of (S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

There total 10 articles about (S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1370248-43-3
(S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

: 1370248-44-4
(S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: With N-Bromosuccinimide; In dichloromethane; for 1h; Reflux;
DOI:10.1021/acs.jmedchem.9b00861

Reference yield:

: 1370248-11-5
ethyl (S)-5-(benzyloxy)-1-(3-hydroxy-1,1-diphenylpropan-2-yl)-6-((2-methoxyethyl)carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

: 1370248-44-4
(S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 h / 20 °C / Cooling with ice

2: sodium hydroxide; water / ethanol / 1.17 h / 20 °C

3: diphenylether / 1 h / 245 °C

4: N-Bromosuccinimide / dichloromethane / 1 h / Reflux

With N-Bromosuccinimide; water; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; diphenylether; ethanol; dichloromethane; toluene;

Reference yield:

: 1370248-12-6
ethyl (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate

: 1370248-44-4
(S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 1.17 h / 20 °C

2: diphenylether / 1 h / 245 °C

3: N-Bromosuccinimide / dichloromethane / 1 h / Reflux

With N-Bromosuccinimide; water; sodium hydroxide; In diphenylether; ethanol; dichloromethane;