[2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: [2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane
• CAS No.: 383125-25-5
• Molecular Formula: C₂₂H₄₀O₆Si
• Molecular Weight: 428.641
• Mol file: 383125-25-5.mol

Synonyms:[2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane

Chemical Property of [2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane

There total 7 articles about [2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + [2,6-Bis-methoxymethoxy-3-((S)-1-methoxy-2-methyl-propyl)-phenyl]-methanol → [2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane (383125-25-5)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0040-4039(01)01657-4

Reference yield:

2,4-bis(methoxymethoxy)benzaldehyde (13709-06-3) → [2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane (383125-25-5)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrahydrofuran / 0 °C

2: pyridine / tetrahydrofuran / -78 °C

3: 92 percent / MeOH; KOH / 20 °C

4: 96 percent / NaH / dimethylformamide / 20 °C

5: s-BuLi; TMEDA / tetrahydrofuran / -78 °C

6: imidazole / dimethylformamide / 20 °C

With pyridine; 1H-imidazole; methanol; potassium hydroxide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)01657-4

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → [2,6-bis-methoxymethoxy-3-(1-methoxy-2-methyl-propyl)-benzyloxy]-tert-butyl-dimethyl-silane (383125-25-5)

Guidance literature:

Multi-step reaction with 7 steps

1: iPr₂NEt / dimethylformamide / 20 °C

2: tetrahydrofuran / 0 °C

3: pyridine / tetrahydrofuran / -78 °C

4: 92 percent / MeOH; KOH / 20 °C

5: 96 percent / NaH / dimethylformamide / 20 °C

6: s-BuLi; TMEDA / tetrahydrofuran / -78 °C

7: imidazole / dimethylformamide / 20 °C

With pyridine; 1H-imidazole; methanol; potassium hydroxide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)01657-4

upstream raw materials:

tert-butyldimethylsilyl chloride

2,4-bis(methoxymethoxy)benzaldehyde

2,4-Dihydroxybenzaldehyde

2,4-Bis-methoxymethoxy-1-((S)-1-methoxy-2-methyl-propyl)-benzene

Downstream raw materials:

tert-butyl-[3-iodo-2,6-bis-methoxymethoxy-5-(1-methoxy-2-methyl-propyl)-benzyloxy]-dimethyl-silane