(4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

Base Information

Chemical Name:(4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>
CAS No.:140385-50-8
Molecular Formula:C₅₄H₇₈N₂O₄P₂
Molecular Weight:881.172
Hs Code.:

(4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

Synonyms:(4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

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Chemical Property of (4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

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Technology Process of (4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

There total 5 articles about (4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 6390-69-8
3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol

: 140385-49-5
(4R,5S)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

: 140385-50-8
(4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

: 140189-32-8
(4S,5R)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine

Guidance literature:: 3,3',5,5'-tetra(tert-butyl)biphenyl-2,2'-diol; With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at 30 ℃; for 1h; Inert atmosphere; Schlenk technique;

(4R,5S)-2-chloro-4-methyl-3-(2-methylpropyl)-5-phenyl-1,3,2-oxazaphospholidine; In tetrahydrofuran; diethyl ether; hexane; at 20 ℃; for 40h; Inert atmosphere; Schlenk technique;
DOI:10.1002/hlca.19910740605

Reference yield:

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 140385-50-8
(4R,4'R,5S,5'S)-4,4'-dimethyl-3,3'-bis(2-methylpropyl)-5,5'-diphenyl-2,2'-<<3,3',5,5'-tetrakis(1,1-dimethylethyl)-1,1'-biphenyl-2,2'-diyl>bis(oxy)>bis<1,3,2-oxazaphospholidine>

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / Heating

2: NaBH₄ / methanol; H₂O / Ambient temperature

3: 40 percent / 1) PCl₃ 2) NEt₃ / CH₂Cl₂ / 1 h / Heating

4: 1) BuLi / hexane, THF

With sodium tetrahydroborate; n-butyllithium; triethylamine; phosphorus trichloride; In methanol; dichloromethane; water; toluene;
DOI:10.1002/hlca.19910740605