(R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

Base Information

Chemical Name:(R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol
CAS No.:1051941-91-3
Molecular Formula:C₁₆H₂₃N₃O₅
Molecular Weight:337.376
Hs Code.:

Synonyms:(R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

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Chemical Property of (R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

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Technology Process of (R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

There total 3 articles about (R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₇N₃O₅

: 1051941-91-3
(R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

Guidance literature:: With acetic acid; In water; at 20 ℃; for 15h; regioselective reaction;
DOI:10.1021/ol8014495

Reference yield:

: 1051942-07-4
C₁₂H₂₁N₃O₅

: 1051941-91-3
(R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 16 h / 0 - 25 °C / Inert atmosphere

2.1: acetic acid / water / 15 h / 20 °C

With sodium hydride; acetic acid; In tetrahydrofuran; water; mineral oil;
DOI:10.1016/j.tet.2020.131495

Reference yield:

: 100-39-0
benzyl bromide

: 1051941-91-3
(R)-1-((4R,5R)-5-((S)-2-azido-1-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 16 h / 0 - 25 °C / Inert atmosphere

2.1: acetic acid / water / 15 h / 20 °C

With sodium hydride; acetic acid; In tetrahydrofuran; water; mineral oil;
DOI:10.1016/j.tet.2020.131495