tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate

Base Information

Chemical Name:tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate
CAS No.:1622406-78-3
Molecular Formula:C₂₀H₂₅ClINO₂Si
Molecular Weight:501.867
Hs Code.:

Synonyms:tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate

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Chemical Property of tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate

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Technology Process of tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate

There total 2 articles about tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 124789-72-6
bis(chloromethyl)(methyl)(phenyl)silane

: 161117-84-6
tert-butyl 2-iodophenylcarbamate

: 1622406-78-3
tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate

Guidance literature:: tert-butyl 2-iodophenylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.0833333h; Inert atmosphere;

bis(chloromethyl)(methyl)(phenyl)silane; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; Inert atmosphere;
DOI:10.1002/chem.201402597

Reference yield:

: 591-50-4
iodobenzene

: 1622406-78-3
tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

1.3: -78 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

2.2: 80 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201402597

Reference yield: 80.0%

: 1622406-78-3
tert-butyl ((chloromethyl)(methyl)(phenyl)silyl)methyl(2-iodophenyl)carbamate

: 1622406-84-1
tert-butyl 4-methyl-4-phenyl-3,4-dihydrobenzo[b][1,4]azasiline-1(2H)-carboxylate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -40 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201402597