3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one

Base Information

Chemical Name:3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one
CAS No.:1268692-22-3
Molecular Formula:C₂₇H₂₃ClF₃NO₅S
Molecular Weight:565.998
Hs Code.:

Synonyms:3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one

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Chemical Property of 3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one

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Technology Process of 3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one

There total 3 articles about 3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 39590-81-3
[1-(hydroxymethyl)cyclopropyl]methanol

: 1202804-39-4
3-(4-bromophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

: 1268692-22-3
3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one

Guidance literature:: 3-(4-bromophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.25h;

[1-(hydroxymethyl)cyclopropyl]methanol; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm1011929

Reference yield:

: 75654-07-8
4'-bromo-o-benzoylbenzoic acid chloride

: 1268692-22-3
3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / 0 °C

2.2: 0 - 20 °C

With boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm1011929

Reference yield:

: 2159-40-2
2-(4-bromobenzoyl)benzoic acid

: 1268692-22-3
3-(4-chlorophenyl)-3-(1-((hydroxymethyl)cyclopropyl)methoxy)-2-(((trifluoromethyl)sulfonyl)benzyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

With thionyl chloride; boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm1011929