3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole

Base Information

• Chemical Name: 3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole
• CAS No.: 110355-39-0
• Molecular Formula: C₁₅H₂₂N₂O₂SSi
• Molecular Weight: 322.503
• Mol file: 110355-39-0.mol

Synonyms:3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole

Chemical Property of 3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole

There total 1 articles about 3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethylsilyl p-tolylsulfonylacetylene (34452-56-7) + 2-diazopropane (2684-60-8) → 3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole (110355-39-0)

Guidance literature:

In diethyl ether; 1.) -78 deg C, 30 min, 2.) 25 deg C, 12 h;

DOI:10.1021/jo00230a020

Reference yield: 99.0%

3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole (110355-39-0) → 3,3-dimethyl-1-(p-tolylsulfonyl)-2-(trimethylsilyl)-cyclopropene (107696-98-0)

Guidance literature:

In benzene; for 2h; Irradiation;

DOI:10.1021/jo00230a020

Reference yield:

3,3-dimethyl-4-(p-tolylsulfonyl)-5-(trimethylsilyl)-3H-pyrazole (110355-39-0) → trans-<2,2-dimethyl-1-(phenylthio)-3-(p-tolylsulfonyl)cyclopropyl>trimethylsilane (110355-53-8,110355-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / benzene / 2 h / Irradiation

2: 1.) n-BuLi / 1.) THF, hexane, from 0 deg C to 25 deg C, 2.) THF, hexane, 25 deg C, 2 h

With n-butyllithium; In benzene;

DOI:10.1021/jo00230a020

upstream raw materials:

trimethylsilyl p-tolylsulfonylacetylene

2-diazopropane

Downstream raw materials:

3,3-dimethyl-1-(p-tolylsulfonyl)-2-(trimethylsilyl)-cyclopropene

[1-Diazo-3-methyl-2-(toluene-4-sulfonyl)-but-2-enyl]-trimethyl-silane

trans-1-<(3-methoxy-1,2,2-trimethylcyclopropyl)sulfonyl>-4-methylbenzene

trans-2,2-dimethyl-3-(p-tolylsulfonyl)cyclopropyl phenyl sulfide