tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

Base Information

Chemical Name:tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate
CAS No.:548757-03-5
Molecular Formula:C₄₇H₆₀O₅Si₂
Molecular Weight:761.161
Hs Code.:

Synonyms:tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

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Technology Process of tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

There total 3 articles about tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 548757-15-9
(S)-2-((2R,2aR,4aS,7R,8aR)-2-Hydroxymethyl-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl)-propionic acid

: 548757-03-5
tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2.75h;
DOI:10.1021/jo034129d

Reference yield:

: 548756-89-4
methyl (3R,4R,5R,11S)-2-acetoxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

: 548757-03-5
tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / H₂O; methanol / 23 h / 40 °C

2: 173 mg / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.75 h / 20 °C

With dmap; potassium hydroxide; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jo034129d

Reference yield:

: 548756-88-3
methyl (3R,4R,5R,11S)-2-acetoxy-3,5-epoxy-1,4-dihydroxy-1,2-secoeudesman-13-oate

: 548757-03-5
tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / triphenylphosphine; diethyl azodicarboxylate / CHCl₃ / 0.5 h / 20 °C

2: KOH / H₂O; methanol / 23 h / 40 °C

3: 173 mg / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.75 h / 20 °C

With dmap; potassium hydroxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; chloroform; water; 1: Mitsunobu reaction;
DOI:10.1021/jo034129d