(3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid

Base Information

Chemical Name:(3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid
CAS No.:548757-04-6
Molecular Formula:C₃₁H₄₂O₅Si
Molecular Weight:522.757
Hs Code.:

Synonyms:(3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid

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Technology Process of (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid

There total 4 articles about (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 548757-03-5
tert-butyl(diphenyl)silyl (3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

: 548757-15-9
(S)-2-((2R,2aR,4aS,7R,8aR)-2-Hydroxymethyl-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl)-propionic acid

: 548757-04-6
(3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid

Guidance literature:: With potassium hydroxide; In methanol; water; at 20 ℃; for 1h;
DOI:10.1021/jo034129d

Reference yield:

: 548757-15-9
(S)-2-((2R,2aR,4aS,7R,8aR)-2-Hydroxymethyl-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl)-propionic acid

: 548757-04-6
(3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 173 mg / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.75 h / 20 °C

2: 82 percent / KOH / H₂O; methanol / 1 h / 20 °C

With dmap; potassium hydroxide; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jo034129d

Reference yield:

: 548756-89-4
methyl (3R,4R,5R,11S)-2-acetoxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

: 548757-04-6
(3R,4R,5R,11S)-2-tert-butyl(diphenyl)silyloxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oic acid

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / H₂O; methanol / 23 h / 40 °C

2: 173 mg / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.75 h / 20 °C

3: 82 percent / KOH / H₂O; methanol / 1 h / 20 °C

With dmap; potassium hydroxide; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jo034129d