N-(4-formyl-5-methyl-2-nitrophenyl)acetamide

Base Information

Chemical Name:N-(4-formyl-5-methyl-2-nitrophenyl)acetamide
CAS No.:126436-28-0
Molecular Formula:C₁₀H₁₀N₂O₄
Molecular Weight:222.2
Hs Code.:
DSSTox Substance ID:DTXSID101258845

Synonyms:N-(4-formyl-5-methyl-2-nitrophenyl)acetamide;126436-28-0;DTXSID101258845

Suppliers and Price of N-(4-formyl-5-methyl-2-nitrophenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-formyl-5-methyl-2-nitrophenyl)acetamide

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:222.06405680
Heavy Atom Count:16
Complexity:300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1C=O)[N+](=O)[O-])NC(=O)C

Technology Process of N-(4-formyl-5-methyl-2-nitrophenyl)acetamide

There total 1 articles about N-(4-formyl-5-methyl-2-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 84257-50-1
4-acetamido-2-methyl benzaldehyde

: 126436-28-0
N-(4-formyl-5-methyl-2-nitrophenyl)acetamide

Guidance literature:: With nitric acid; at -40 - -20 ℃; for 0.666667h;
DOI:10.1248/cpb.42.560

Reference yield: 96.0%

: 126436-28-0
N-(4-formyl-5-methyl-2-nitrophenyl)acetamide

: 1449416-36-7
4-amino-2-methyl-5-nitrobenzaldehyde

Guidance literature:: With hydrogenchloride; In methanol; water; Reflux; Inert atmosphere;
DOI:10.1021/ja406077j

Reference yield:

: 126436-28-0
N-(4-formyl-5-methyl-2-nitrophenyl)acetamide

: 1026893-14-0
N-[2-Amino-5-methyl-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / acetic acid / 0.25 h / 100 °C

2: 52.6 percent / P(OEt)3 / dimethylformamide / 80 °C

3: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h / 760 Torr / Ambient temperature

With ammonium acetate; hydrogen; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.560