33-O-tert.butyldimethylsilyl-FK-506

Base Information

Chemical Name:33-O-tert.butyldimethylsilyl-FK-506
CAS No.:104987-25-9
Molecular Formula:C₅₀H₈₃NO₁₂Si
Molecular Weight:918.294
Hs Code.:

Synonyms:33-O-tert.butyldimethylsilyl-FK-506

Suppliers and Price of 33-O-tert.butyldimethylsilyl-FK-506

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
33-tert-Butyldimethylsilyloxy-FK506
50mg
$ 925.00

Total 5 raw suppliers

Chemical Property of 33-O-tert.butyldimethylsilyl-FK-506

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

33-tert-Butyldimethylsilyloxy-FK506 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 33-tert-Butyldimethylsilyloxy-FK 506 is an intermediate in the synthesis of Iso-FK-506 (iso-Tacrolimus) (I816250), which is an isomer of FK-506 (F370000) from fermentation of Streptomyces tsukubaensis, as immunosuppressant and antiinflammatory agent.

Technology Process of 33-O-tert.butyldimethylsilyl-FK-506

There total 2 articles about 33-O-tert.butyldimethylsilyl-FK-506 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104987-11-3
Tacrolimus

: 18162-48-6
tert-butyldimethylsilyl chloride

: 104987-25-9
33-O-tert.butyldimethylsilyl-FK-506

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89004-9

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 104987-11-3
Tacrolimus

: 104987-25-9
33-O-tert.butyldimethylsilyl-FK-506

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane;
DOI:10.1016/S0040-4039(00)79671-7

Reference yield: 66.0%

: 104987-25-9
33-O-tert.butyldimethylsilyl-FK-506

: 134556-80-2,140852-70-6
C₅₀H₈₅NO₁₂Si

: 134556-80-2,140852-70-6
33-O-tert-butyldimethylsilyl-22(S)-dihydro-FK-506

Guidance literature:: With tetramethylammonium triacetoxyborohydride; In acetic acid; acetonitrile; at -5 - 0 ℃; for 5h;
DOI:10.1016/S0040-4020(01)89004-9