N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

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Chemical Name:N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one
CAS No.:135674-98-5
Molecular Formula:C₂₆H₄₃N₅O₆
Molecular Weight:521.657
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

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Chemical Property of N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

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Technology Process of N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

There total 2 articles about N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 61070-20-0
N^α-(tert-butoxycarbony1)- N^τ-methyl-L-histidine

: 122225-24-5
(1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

: 135674-98-5
N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; 1.) -23 deg C, 2 h, 2.) RT, 15 h;
DOI:10.1021/jm00056a005

Reference yield:

: (1'R,2'S,5S)-5-<2'-<(tert-butyloxycarbonyl)amino>-3'-cyclohexyl-1'-(methoxymethoxy)propyl>-3-ethyloxazolidin-2-one

: 135674-98-5
N-(tert-butyloxycarbonyl)-τ-methyl-L-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 4.5 M ethanolic HCl / 1 h / Ambient temperature

2: 86 percent / 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 15 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00056a005