2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 885274-64-6
• Molecular Formula: C13H13 N O4
• Molecular Weight: 247.25
• Hs Code.: 2934999090
• Mol file: 885274-64-6.mol

Synonyms:2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 384.9±48.0 °C(Predicted)
• PKA: -1?+-.0.10(Predicted)
• PSA: 61.56000
• Density: 1.182±0.06 g/cm3(Predicted)
• LogP: 2.52690

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(2-methoxyphenyl)oxazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + 2-methoxyphenyl 1H-imidazole-1-sulfonate (1207429-55-7) → ethyl 2-(2-methoxyphenyl)oxazole-4-carboxylate (885274-64-6)

Guidance literature:

With palladium diacetate; caesium carbonate; 1,2-bis-(diphenylphosphino)ethane; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 14h; Inert atmosphere;

DOI:10.1021/ol9028034

Reference yield: 76.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + 4-iodoanisol (529-28-2) → ethyl 2-(2-methoxyphenyl)oxazole-4-carboxylate (885274-64-6)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; In toluene; at 110 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00530

Reference yield: 66.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + 2-bromoanisole (578-57-4) → ethyl 2-(2-methoxyphenyl)oxazole-4-carboxylate (885274-64-6)

Guidance literature:

With C₂H₃O₂^(1-)*C₂₀H₃₀OP^(1-)*C₂₀H₃₁OP*Pd⁽²⁺⁾; caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol200986x

upstream raw materials:

oxazole-4-carboxylic acid ethyl ester

2-methoxyphenyl 1H-imidazole-1-sulfonate

2-bromoanisole

4-iodoanisol

Downstream raw materials:

ethyl 2-(2-methoxyphenyl)-5-phenyloxazole-4-carboxylate