dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate

Base Information

• Chemical Name: dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate
• CAS No.: 1478648-87-1
• Molecular Formula: C₂₅H₂₇IN₂O₆S
• Molecular Weight: 610.47
• Mol file: 1478648-87-1.mol

Synonyms:dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate

Chemical Property of dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate

There total 5 articles about dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

dimethyl 2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate (1478648-84-8) → dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate (1478648-87-1)

Guidance literature:

dimethyl 2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 ℃; for 0.25h;

With iodine; In tetrahydrofuran;

DOI:10.1055/s-0033-1338969

Reference yield:

C18H22N2O4 (1478648-81-5) → dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate (1478648-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -40 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-0033-1339472 DOI:10.1055/s-0033-1338969

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → dimethyl 2-io do-2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate (1478648-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -40 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-0033-1339472 DOI:10.1055/s-0033-1338969

upstream raw materials:

dimethyl 2-(2-(2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)ethyl)malonate

C₁₈H₂₂N₂O₄

p-toluenesulfonyl chloride

malonic acid dimethyl ester