5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile

Base Information

Chemical Name:5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile
CAS No.:1307812-65-2
Molecular Formula:C₂₁H₁₇BrN₂O₂
Molecular Weight:409.282
Hs Code.:

Synonyms:5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile

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Chemical Property of 5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile

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Technology Process of 5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile

There total 2 articles about 5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 213598-11-9
methyl 3-cyano-4-[(1-methylethyl)oxy]benzoate

: 66361-68-0
N-[6-bromo-1,2,3,4-tetrahydronaphthalen-1-ylidene]hydroxylamine

: 1307812-65-2
5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile

Guidance literature:: N-[6-bromo-1,2,3,4-tetrahydronaphthalen-1-ylidene]hydroxylamine; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.266667h;

methyl 3-cyano-4-[(1-methylethyl)oxy]benzoate; In tetrahydrofuran; at 0 ℃; for 0.183333h;

With toluene-4-sulfonic acid; In toluene; at 20 - 110 ℃; for 0.416667h; Sonication;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1307812-65-2
5-(7-bromo-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)-2-isopropoxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: diazomethyl-trimethyl-silane / dichloromethane / 1.8 h / 0 - 20 °C

1.2: 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.27 h / 0 °C

2.2: 0.18 h / 0 °C

2.3: 0.42 h / 20 - 110 °C / Sonication

With lithium diisopropyl amide; diazomethyl-trimethyl-silane; In tetrahydrofuran; dichloromethane;