(R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone

Base Information

Chemical Name:(R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone
CAS No.:142705-76-8
Molecular Formula:C₁₇H₁₉NO₄S
Molecular Weight:333.408
Hs Code.:

Synonyms:(R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone

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Technology Process of (R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone

There total 8 articles about (R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 103795-14-8
(1R)-2-O-benzyl-3,4-O-isopropylidene-1-(2-thiazolyl)-D-erythritol

: 142705-76-8
(R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone

Guidance literature:: With acetic anhydride; dimethyl sulfoxide; for 14h; Ambient temperature;
DOI:10.1055/s-1992-34170

Reference yield:

: 100-39-0
benzyl bromide

: 142705-76-8
(R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH, 2.) Bu₄NI / 1.) THF, reflux, 20 min, 2.) r. t., 14 h

2: acetonitrile / Heating

3: NaBH₄ / methanol / 0.5 h / Ambient temperature

4: HgCl₂ / acetonitrile; H₂O / 0.33 h / Ambient temperature

5: 2.) Bu₄NF / 1.) THF, r. t., 14 h, 2.) r. t., 2 h

6: 88 percent / DMSO, Ac₂O / 14 h / Ambient temperature

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; mercury dichloride; In methanol; water; acetonitrile;
DOI:10.1055/s-1992-34170

Reference yield:

: 103795-11-5
(1R)-1-O-benzyl-2,3-O-isopropylidene-1-(2-thiazolyl)-D-glycitol

: 142705-76-8
(R)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / Heating

2: NaBH₄ / methanol / 0.5 h / Ambient temperature

3: HgCl₂ / acetonitrile; H₂O / 0.33 h / Ambient temperature

4: 2.) Bu₄NF / 1.) THF, r. t., 14 h, 2.) r. t., 2 h

5: 88 percent / DMSO, Ac₂O / 14 h / Ambient temperature

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; acetic anhydride; dimethyl sulfoxide; mercury dichloride; In methanol; water; acetonitrile;
DOI:10.1055/s-1992-34170