acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester

Base Information

Chemical Name:acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester
CAS No.:845508-85-2
Molecular Formula:C₂₀H₃₂O₃Si
Molecular Weight:348.558
Hs Code.:

Synonyms:acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester

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Chemical Property of acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester

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Technology Process of acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester

There total 1 articles about acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 235090-81-0
Acetic acid 3-hydroxy-2-methylene-5-phenyl-pentyl ester

: 845508-85-2
acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jo0482209

Reference yield: 63.0%

: 845508-85-2
acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester

: 845508-86-3
3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenylpentanol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jo0482209

Reference yield:

: 845508-85-2
acetic acid 3-[(tert-butyl)(dimethyl)silanyloxy]-2-methylidene-5-phenyl-pentyl ester

: E-(tert-butyl)(dimethyl)(2-methylidene-1-phenethyl-pent-3-enyloxy)silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 63 percent / K₂CO₃ / methanol / 2 h / 20 °C

2.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -50 - 25 °C

3.1: KHMDS / tetrahydrofuran / 0 °C

3.2: 59.2 percent / tetrahydrofuran / -78 - 20 °C

4.1: Grubbs catalyst / benzene-d6 / 30 °C

With Grubbs catalyst first generation; oxalyl dichloride; potassium hexamethylsilazane; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; benzene-d6; 2.1: Swern oxidation;
DOI:10.1021/jo0482209