C₂₄H₃₃FN₆O₉P^(1-)*Na⁽¹⁺⁾

Base Information

• Chemical Name: C₂₄H₃₃FN₆O₉P^(1-)*Na⁽¹⁺⁾
• CAS No.: 1379798-26-1
• Molecular Formula: C₂₄H₃₃FN₆O₉P*Na
• Molecular Weight: 622.523
• Mol file: 1379798-26-1.mol

Synonyms:C₂₄H₃₃FN₆O₉P^(1-)*Na⁽¹⁺⁾

Chemical Property of C₂₄H₃₃FN₆O₉P^(1-)*Na⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₃₃FN₆O₉P^(1-)*Na⁽¹⁺⁾

There total 6 articles about C₂₄H₃₃FN₆O₉P^(1-)*Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-acetyllysinamide hydrochloride + C16H16FN3O8P(1-)*Na(1+) (1379798-21-6) → C24H33FN6O9P(1-)*Na(1+) (1379798-26-1)

Guidance literature:

N-acetyllysinamide hydrochloride; C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾; In glycerol; for 1h; Inert atmosphere;

With sodium cyanoborohydride; In glycerol; at 20 ℃; for 48h; Inert atmosphere;

In water; Inert atmosphere;

DOI:10.1002/chem.201103270

Reference yield: 33.0%

N-acetyllysinamide hydrochloride + C16H16FN3O8P(1-)*Na(1+) (1379798-21-6) → C16H18FN3O8P(1-)*Na(1+) (1379798-29-4) + C24H33FN6O9P(1-)*Na(1+) (1379798-26-1)

Guidance literature:

N-acetyllysinamide hydrochloride; C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾; In glycerol; for 1h; Inert atmosphere;

With sodium cyanoborohydride; In glycerol; at 20 ℃; for 48h; Inert atmosphere;

In water; Inert atmosphere;

DOI:10.1002/chem.201103270

Reference yield:

5-Iodo-2'-deoxycytidine (611-53-0) → C24H33FN6O9P(1-)*Na(1+) (1379798-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trimethyl phosphite; trichlorophosphate / 6 h / 0 - 80 °C / Inert atmosphere

1.2: Dowex 50WX₈ in Na⁺ cycle / Inert atmosphere

2.1: trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; caesium carbonate / water; acetonitrile / 1.5 h / 75 °C / Inert atmosphere

2.2: Dowex 50WX₈ in Na⁺ cycle / Inert atmosphere

3.1: glycerol / 1 h / Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

3.3: Dowex 50WX₈ in Na⁺ cycle / Inert atmosphere

With trimethyl phosphite; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; caesium carbonate; trichlorophosphate; In water; glycerol; acetonitrile; 2.1: Suzuki coupling;

DOI:10.1002/chem.201103270

upstream raw materials:

C₁₆H₁₆FN₃O₈P^(1-)*Na⁽¹⁺⁾

(2-fluoro-5-formylphenyl)boronic acid

5-iodo-2'-deoxycytidine monophosphate

5-Iodo-2'-deoxycytidine