[4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol

Base Information

Chemical Name:[4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol
CAS No.:211857-41-9
Molecular Formula:C₁₅H₂₁F₃O₄
Molecular Weight:322.325
Hs Code.:

Synonyms:[4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol

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Technology Process of [4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol

There total 1 articles about [4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 211857-40-8
tert-Butyl-diphenyl-[4-((1S,2R,3S)-4,4,4-trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-benzyloxy]-silane

: 211857-41-9
[4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1002/hlca.19980810515

Reference yield: 80.0%

: 211857-41-9
[4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol

: 211857-42-0
1-Bromomethyl-4-((1S,2R,3S)-4,4,4-trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-benzene

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1002/hlca.19980810515

Reference yield:

: 211857-41-9
[4-((1S,2R,3S)-4,4,4-Trifluoro-1,3-dimethoxy-2-methoxymethyl-butyl)-phenyl]-methanol

: C₅₇H₇₁BrF₁₂O₁₂

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Ph₃P, CBr₄ / tetrahydrofuran / 16 h / Ambient temperature

2: 1.) NaH / 1.) THF, r.t., 30 min; 2.) THF, reflux, 19 h

3: 81 percent / TBAF / tetrahydrofuran / 16 h / Ambient temperature

4: 86 percent / Ph₃P, CBr₄ / tetrahydrofuran / 40 h / Ambient temperature

With carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; In tetrahydrofuran;
DOI:10.1002/hlca.19980810515