1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid

Base Information

Chemical Name:1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid
CAS No.:1314389-37-1
Molecular Formula:C₁₂H₆FN₃O₃
Molecular Weight:259.196
Hs Code.:

Synonyms:1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid

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Chemical Property of 1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid

Chemical Property:

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Technology Process of 1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid

There total 2 articles about 1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl (2E)-2-[2-(3-cyano-5-fluorophenyl)hydrazinylidene]-3-oxobutanoate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1314389-37-1
1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid

Guidance literature:: benzyl (2E)-2-[2-(3-cyano-5-fluorophenyl)hydrazinylidene]-3-oxobutanoate; N,N-dimethyl-formamide dimethyl acetal; at 75 ℃; for 5h;

With pyridine; sodium iodide; at 100 ℃; for 20h;

With hydrogenchloride; In water;

Reference yield:

: 210992-28-2
3-amino-5-fluoro-benzonitrile

: 1314389-37-1
1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1.25 h / 0 - 4 °C

1.2: 1 h / 0 °C

2.1: 5 h / 75 °C

2.2: 20 h / 100 °C

With hydrogenchloride; sodium nitrite; In water;

Reference yield:

: 1314389-37-1
1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid

: 1314389-38-2
3-fluoro-5-[3-(hydroxymethyl)-4-oxopyridazin-1(4H)-yl]benzonitrile

Guidance literature:: 1-(3-cyano-5-fluorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 1h;