210992-28-2

Basic information

• Product Name: 5-Amino-3-fluorobenzonitrile
• Synonyms: 5-AMINO-3-FLUOROBENZONITRILE;5-CYANO-3-FLUOROANILINE;5-Cyano-3-fluoroaniline 98%;5-Amino-3-fluorobenzonitrile 98%;3-Cyano-5-fluoroaniline;3-Fluoro-5-aminobenzonitrile;5-Amino-3-fluorobenzonitrile ,95%;3-Amino-5-fluorobenzonitrile 98%
• CAS NO: 210992-28-2
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.13
• Product Categories: Aromatic Nitriles;Fluorine series
• Mol File: 210992-28-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 288.6 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /
• Density: 1.25
• Vapor Pressure: 0.48mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.77±0.10(Predicted)
• CAS DataBase Reference: 5-Amino-3-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-3-fluorobenzonitrile(210992-28-2)
• EPA Substance Registry System: 5-Amino-3-fluorobenzonitrile(210992-28-2)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3439
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 210992-28-2(Hazardous Substances Data)

Usage

General Description

5-Amino-3-fluorobenzonitrile is a chemical compound with the molecular formula C7H5FN2. It is a white crystalline powder that is commonly used as an intermediate in the synthesis of pharmaceutical and agrochemical products. 5-Amino-3-fluorobenzonitrile is known for its versatility and is used in the production of various organic chemicals. It has a variety of applications in the pharmaceutical industry, including the synthesis of antiviral and anticancer drugs. Additionally, 5-Amino-3-fluorobenzonitrile is also used as an intermediate in the production of agrochemicals such as herbicides and insecticides. Due to its importance in the synthesis of various valuable compounds, 5-Amino-3-fluorobenzonitrile is an important building block in the chemical industry.

InChI:InChI=1/C8H6BrF3S/c9-5-6-1-3-7(4-2-6)13-8(10,11)12/h1-4H,5H2

Upstream product

• 557-21-1 dicyanozinc 
• 134168-97-1 3-bromo-5-fluoroaniline 
• 3819-88-3 1-fluoro-3-iodo-5-nitrobenzene 
• 807620-95-7 N-(3-bromo-5-fluorophenyl)acetamide 
• 1435-51-4 1,3-dibromo-5-fluorobenzene 
• 110882-60-5 3-fluoro-5-nitrobenzonitrile 
• 64248-63-1 3,5-difluorobenzonitrile 

Downstream Products

• 903556-38-7 C₁₅H₁₁FN₂O₂ 
• 1260487-50-0 1-(2-chloro-4-trifluoromethylphenyl)-3-(3-fluoro-5-formylphenyl)urea 
• 1260487-53-3 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide 
• 1260487-55-5 1-(2-fluoro-4-trifluoromethylphenyl)-3-(3-fluoro-5-formylphenyl)urea 
• 1260487-47-5 4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide 
• 1260487-52-2 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide hydrochloride 
• 1260487-54-4 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide) 
• 939999-18-5 N-(5-cyano-3-fluorophenyl)acetamide 

Relevant articles and documents

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes

A series of novel 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)- 4-pyrazolyl]-1-trans-propenes and related compounds were synthesized and evaluated by their cytotoxic activity against several tumor cell lines in vitro and in vivo antitumor acti

5-FLUORO-, CHLORO- AND CYANO-PYRIDIN-2-YL-TETRAZOLES AS LIGANDS OF THE METABOTROPIC GLUTAMATE RECEPTOR-5

The present invention relates to new compounds of formula I, wherein Z, Q, X1, X2, R1 and R2, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity

The highly potent, selective, and brain-penetrant metabotropic glutamate subtype 5 (mGlu5) receptor antagonists 3-(5-pyridin-2-yl-2H-tetrazol-2-yl) benzonitrile (47) and 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile (48) are reported. Compound 47 is active in the rat fear-potentiated startle (FPS) model of anxiety with ED50 = 5.4 mg/kg (po) when dosed acutely. In this model the anxiolytic effects of 47 rapidly tolerate on repeated dosing.