2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346448-12-1
Molecular Formula:C₂₂H₂₁ClN₆O₃
Molecular Weight:452.9
Hs Code.:

Synonyms:2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

There total 5 articles about 2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 50536-99-7
3-nitro-5,6,7,8-tetrahydro-[1]naphthylamine

: 1346448-12-1
2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With toluene-4-sulfonic acid; In isopropyl alcohol; at 90 ℃; for 12h;

Reference yield:

: 4141-08-6
2-Amino-N-methylbenzamid

: 1346448-12-1
2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2: toluene-4-sulfonic acid / isopropyl alcohol / 12 h / 90 °C

With potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 119-64-2
tetralin

: 1346448-12-1
2-((5-chloro-2-((3-nitro-5,6,7,8-tetrahydronaphthalen-1-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: nitric acid; sulfuric acid / 0.5 h / 0 °C

2: hydrogenchloride; tin(ll) chloride; acetic acid / ethanol; water / 5 h / Reflux

3: toluene-4-sulfonic acid / isopropyl alcohol / 12 h / 90 °C

With hydrogenchloride; sulfuric acid; nitric acid; toluene-4-sulfonic acid; acetic acid; tin(ll) chloride; In ethanol; water; isopropyl alcohol;