2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

Base Information

Chemical Name:2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol
CAS No.:1261174-82-6
Molecular Formula:C₁₄H₁₂ClFN₄O
Molecular Weight:312.679
Hs Code.:

Synonyms:2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

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Chemical Property of 2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

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Technology Process of 2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

There total 2 articles about 2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 666-52-4
[⁽²⁾H₆]acetone

: 233276-27-2
6-chloro-3-(2-fluorophenyl)-7-(trimethylsilyl)-[1,2,4]triazolo[4,3-b]pyridazine

: 1261174-82-6
2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

Guidance literature:: With tetra-n-butylammonium difluorotriphenylstannate; at 20 ℃; for 5h;

Reference yield:

: 3-Chloro-6-[2-(2-fluorobenzoyl)hydrazino]-4-(trimethylsilyl)-pyridazine

: 1261174-82-6
2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; 1,2-dibromo-1,1,2,2-tetrachloroethane / acetonitrile / 5 - 7 °C

1.2: 5 - 7 °C / Cooling with ice

2.1: tetra-n-butylammonium difluorotriphenylstannate / 5 h / 20 °C

With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine; tetra-n-butylammonium difluorotriphenylstannate; In acetonitrile;

Reference yield:

: 215868-81-8
(2-ethyl-2H-[1,2,4]triazol-3-yl)methanol

: 1261174-82-6
2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

: 1261174-58-6
2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

Guidance literature:: (2-ethyl-2H-[1,2,4]triazol-3-yl)methanol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil; for 0.25h;

2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20 ℃; for 2h;