2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

Base Information

Chemical Name:2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol
CAS No.:1261174-58-6
Molecular Formula:C₁₉H₂₀FN₇O₂
Molecular Weight:403.364
Hs Code.:

Synonyms:2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

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Chemical Property of 2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

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Technology Process of 2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

There total 3 articles about 2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 215868-81-8
(2-ethyl-2H-[1,2,4]triazol-3-yl)methanol

: 1261174-82-6
2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol

: 1261174-58-6
2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

Guidance literature:: (2-ethyl-2H-[1,2,4]triazol-3-yl)methanol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; mineral oil; for 0.25h;

2-(6-chloro-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-propan-1,1,1,3,3,3-d6-2-ol; In 1-methyl-pyrrolidin-2-one; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 3-Chloro-6-[2-(2-fluorobenzoyl)hydrazino]-4-(trimethylsilyl)-pyridazine

: 1261174-58-6
2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; 1,2-dibromo-1,1,2,2-tetrachloroethane / acetonitrile / 5 - 7 °C

1.2: 5 - 7 °C / Cooling with ice

2.1: tetra-n-butylammonium difluorotriphenylstannate / 5 h / 20 °C

3.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.25 h

3.2: 2 h / 20 °C

With 1,2-dibromo-1,1,2,2-tetrachloroethane; sodium hydride; triphenylphosphine; tetra-n-butylammonium difluorotriphenylstannate; In 1-methyl-pyrrolidin-2-one; acetonitrile; mineral oil;

Reference yield:

: 233276-27-2
6-chloro-3-(2-fluorophenyl)-7-(trimethylsilyl)-[1,2,4]triazolo[4,3-b]pyridazine

: 1261174-58-6
2-(6-((1-ethyl-1H-1,2,4-triazol-5-yl)methoxy)-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)propan-1,1,1,3,3,3-d6-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-n-butylammonium difluorotriphenylstannate / 5 h / 20 °C

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.25 h

2.2: 2 h / 20 °C

With sodium hydride; tetra-n-butylammonium difluorotriphenylstannate; In 1-methyl-pyrrolidin-2-one; mineral oil;