OXAZOLE-4-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: OXAZOLE-4-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 885274-12-4
• Molecular Formula: C4H5 N3 O2
• Molecular Weight: 127.103
• Hs Code.: 2934999090
• Mol file: 885274-12-4.mol

Synonyms:OXAZOLE-4-CARBOXYLIC ACID HYDRAZIDE

Chemical Property of OXAZOLE-4-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• Refractive Index: 1.539
• PKA: 10.85±0.10(Predicted)
• PSA: 81.15000
• Density: 1.367g/cm³
• LogP: 0.36930
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

Oxazole-4-carboxylic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Oxazole-4-carbohydrazide is a useful reagent for the preparation 6-heteroarylamino-2,4,5-trimethylpyridin-3-ol derivatives for prevention or treatment of inflammatory bowel diseases and autoimmune diseases.

Technology Process of OXAZOLE-4-CARBOXYLIC ACID HYDRAZIDE

There total 1 articles about OXAZOLE-4-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) → 4-oxazolecarboxylic acid hydrazide (885274-12-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 25 ℃; for 1h;

DOI:10.3987/COM-20-14355

Reference yield: 84.8%

4-oxazolecarboxylic acid hydrazide (885274-12-4) + 4-bromo-benzaldehyde (1122-91-4) → 4-oxazolecarboxylic acid 2-(4 -bromophenyl)methylenehydrazide

Guidance literature:

In ethanol; at 75 ℃; for 4h;

DOI:10.3987/COM-20-14355

Reference yield: 78.8%

4-oxazolecarboxylic acid hydrazide (885274-12-4) + 4-fluorobenzaldehyde (459-57-4) → 4-oxazolecarboxylic acid 2-(4 -fluorophenyl)methylenehydrazide

Guidance literature:

In ethanol; at 75 ℃; for 4h;

DOI:10.3987/COM-20-14355

upstream raw materials:

oxazole-4-carboxylic acid ethyl ester

Refernces