N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide
• CAS No.: 1620657-92-2
• Molecular Formula: C₂₆H₂₅N₂O₄PS
• Molecular Weight: 492.535
• Mol file: 1620657-92-2.mol

Synonyms:N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide

Chemical Property of N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide

There total 5 articles about N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-(aminomethyl)-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1439568-51-0) + p-toluenesulfonyl chloride (98-59-9) → N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide (1620657-92-2)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; at 23 ℃; for 18h; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.201400120

Reference yield:

2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione (628308-52-1) → N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide (1620657-92-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 16 h / 120 °C / Inert atmosphere; Schlenk technique

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

3: hydrazine hydrate / methanol / 16 h / 90 °C / Inert atmosphere; Schlenk technique

4: sodium hydroxide / water; diethyl ether / 18 h / 23 °C / Inert atmosphere; Schlenk technique

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In methanol; diethyl ether; dichloromethane; water;

DOI:10.1002/ejoc.201400120

Reference yield:

2-({6-[(diphenylphosphoryl)methyl]pyridin-2-yl}methyl)isoindoline-1,3-dione (1620657-78-4) → N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide (1620657-92-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

2: hydrazine hydrate / methanol / 16 h / 90 °C / Inert atmosphere; Schlenk technique

3: sodium hydroxide / water; diethyl ether / 18 h / 23 °C / Inert atmosphere; Schlenk technique

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In methanol; diethyl ether; dichloromethane; water;

DOI:10.1002/ejoc.201400120

upstream raw materials:

2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione

2-({6-[(diphenylphosphoryl)methyl]pyridin-2-yl}methyl)isoindoline-1,3-dione

2,6-bis(chloromethyl)pyridine

2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide