(S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

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Chemical Name:(S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine
CAS No.:1422052-07-0
Molecular Formula:C₂₅H₂₇F₂N₅O₄S₂
Molecular Weight:563.649
Hs Code.:

Synonyms:(S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

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Chemical Property of (S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

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Technology Process of (S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

There total 10 articles about (S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259279-57-6
5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1422052-06-9
(S)-2-chloro-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoropyrimidin-4-amine

: 1422052-07-0
(S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

Guidance literature:: 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; (S)-2-chloro-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoropyrimidin-4-amine; With potassium phosphate; In 2-methyltetrahydrofuran; water; for 0.5h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; water; at 120 ℃; for 2h;

Reference yield:

: 1422052-02-5
(S)-2-(2-chloro-5-fluoropyrimidin-4-ylamino)-3,3-dimethylbutyl methanesulfonate

: 1422052-07-0
(S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 1 h / 78 °C

2.1: methanol; sodium methylate / 1 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 1.3 h / 70 °C

4.1: Oxone / methanol / 3 h / 0 - 20 °C

5.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.5 h / Inert atmosphere

5.2: 2 h / 120 °C

With methanol; Oxone; potassium phosphate; sodium methylate; potassium carbonate; In 2-methyltetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1422052-05-8
(S)-2-chloro-N-(3,3-dimethyl-1-(methylthio)butan-2-yl)-5-fluoropyrimidin-4-amine

: 1422052-07-0
(S)-N-(3,3-dimethyl-1-(methylsulfonyl)butan-2-yl)-5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Oxone / methanol / 3 h / 0 - 20 °C

2.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.5 h / Inert atmosphere

2.2: 2 h / 120 °C

With Oxone; potassium phosphate; In 2-methyltetrahydrofuran; methanol; water;