methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate

Base Information

• Chemical Name: methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate
• CAS No.: 936355-50-9
• Molecular Formula: C₂₁H₂₂O₃
• Molecular Weight: 322.404
• Mol file: 936355-50-9.mol

Synonyms:methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate

Chemical Property of methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate

There total 2 articles about methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) + 2,2-Diphenylcyclopropancarbonsaeurechlorid (7746-95-4) → methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate (936355-50-9)

Guidance literature:

Methyl isobutyrate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

2,2-Diphenylcyclopropancarbonsaeurechlorid; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1021/ol070593j

Reference yield:

2,2-diphenyl-cyclopropanecarboxylic acid (7150-12-1) → methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate (936355-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl chloride / benzene

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 92 percent / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; oxalyl dichloride; diisopropylamine; In tetrahydrofuran; hexane; benzene;

DOI:10.1021/ol070593j

Reference yield: 95.0%

methyl 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate (936355-50-9) → 3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoic acid (936355-51-0)

Guidance literature:

With lithium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1021/ol070593j

upstream raw materials:

Methyl isobutyrate

2,2-Diphenylcyclopropancarbonsaeurechlorid

2,2-diphenyl-cyclopropanecarboxylic acid

Downstream raw materials:

3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoic acid

3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-3-(2,2-diphenylcyclopropyl)-2,2-dimethyl-3-oxopropanoate