2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine

Base Information

• Chemical Name: 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine
• CAS No.: 82921-43-5
• Molecular Formula: C₃₇H₅₃N₅O₉S
• Molecular Weight: 743.922

Synonyms:2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine

Chemical Property of 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine

There total 3 articles about 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) + 2'-deoxy-N2-isobutyrylguanosine 3',5'-diisobutyrate (82921-42-4) → 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine (82921-43-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(00)87314-1

Reference yield:

2'-Deoxyguanosine (961-07-9) → 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine (82921-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / pyridine / 1 h

2: Et₃N / 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

With triethylamine; dmap; In pyridine; dichloromethane;

DOI:10.1016/0040-4020(84)85098-X

Reference yield:

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) + 2-N,3'-O,5'-O-triisobutyryl-2'-deoxyguanosine → 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine (82921-43-5)

Guidance literature:

With triethylamine; dmap; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/0040-4020(84)85098-X

upstream raw materials:

2,4,6-triisopropylphenylsulfonyl chloride

2'-deoxy-N²-isobutyrylguanosine 3',5'-diisobutyrate

2'-Deoxyguanosine

Downstream raw materials:

N-[9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-(2-phenylsulfanyl-ethoxy)-9H-purin-2-yl]-isobutyramide

N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenylsulfanyl)-ethoxy]-9H-purin-2-yl}-isobutyramide

2-Isobutyramido-N⁶-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxyadenosine

5'-O-(4,4'-Dimethoxytrityl)-2-isobutyramido-N⁶-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxyadenosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 82921-43-5 2-N-3',5'-O-triisobutyryl-6-O-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxyguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send