Technology Process of methyl 7α-acetoxy-1β,3β-dihydroxy-5β-cholan-24-oate
There total 2 articles about methyl 7α-acetoxy-1β,3β-dihydroxy-5β-cholan-24-oate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 3.67 g / N,N-dimethylaminopyridine, Et3N / CH2Cl2 / 1.5 h
2: Br2 / acetic acid / 1 h / Ambient temperature
3: 2.13 g / Li2CO3, LiBr / dimethylformamide / 4 h / 80 °C
4: 987 mg / Zn dust / acetone; acetic acid / 1 h / Ambient temperature
5: 30 percent H2O2, 2 N NaOH / tetrahydrofuran; ethanol / 6 h / Ambient temperature
6: diethyl ether
7: 336 mg / Cr(OAc)2 / ethanol / 2 h / Ambient temperature
8: 241 mg / NaBH4 / propan-2-ol / 0.5 h
With
dmap; sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; bromine; lithium carbonate; chromium(II) acetate; triethylamine; lithium bromide; zinc;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1248/cpb.34.2890
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 3.67 g / N,N-dimethylaminopyridine, Et3N / CH2Cl2 / 1.5 h
2: Br2 / acetic acid / 1 h / Ambient temperature
3: 2.13 g / Li2CO3, LiBr / dimethylformamide / 4 h / 80 °C
4: 987 mg / Zn dust / acetone; acetic acid / 1 h / Ambient temperature
5: 30 percent H2O2, 2 N NaOH / tetrahydrofuran; ethanol / 6 h / Ambient temperature
6: diethyl ether
7: 336 mg / Cr(OAc)2 / ethanol / 2 h / Ambient temperature
8: 110 mg / NaBH4 / propan-2-ol / 0.5 h
With
dmap; sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; bromine; lithium carbonate; chromium(II) acetate; triethylamine; lithium bromide; zinc;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1248/cpb.34.2890
- Guidance literature:
-
With
lithium hydroxide;
In
methanol;
for 1h;
Heating;
DOI:10.1248/cpb.34.2890
