N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine

Base Information

Chemical Name:N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine
CAS No.:182289-72-1
Molecular Formula:C₁₂H₁₁ClF₃N₃O₄S
Molecular Weight:385.751
Hs Code.:

Synonyms:N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine

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Chemical Property of N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine

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Technology Process of N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine

There total 6 articles about N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 182289-69-6
4-chloro-1-methyl-5-methanesulfonyl-3-[3-nitro-4-(trifluoromethyl)phenoxy]pyrazole

: 182289-72-1
N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine

Guidance literature:: With selenium; sodium tetrahydroborate; In ethanol;
DOI:10.1021/jf9601978

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 182289-72-1
N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10percent Pd/C / ethanol / 15 h / 2585.7 Torr

2: 3 h / Heating

3: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

4: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

5: 91 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 10 h

6: 100 percent / NaBH₄, Se / ethanol

With hydrogenchloride; selenium; sodium tetrahydroborate; tert.-butylnitrite; sulfuric acid; hydrogen; nitric acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jf9601978

Reference yield:

: 535-52-4
2-fluoro-5-(trifluoromethyl)aniline

: 182289-72-1
N-[5-(4-Chloro-5-methanesulfonyl-1-methyl-1H-pyrazol-3-yloxy)-2-trifluoromethyl-phenyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 3 h / Heating

2: 1.) conc. H₂SO₄, HNO₃, 2.) 12 N aq. HCl, 3.) t-BuONO

3: 65 percent / K₂CO₃ / dimethylsulfoxide / 24 h / 80 °C

4: 91 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 10 h

5: 100 percent / NaBH₄, Se / ethanol

With hydrogenchloride; selenium; sodium tetrahydroborate; tert.-butylnitrite; sulfuric acid; nitric acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jf9601978