4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

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Chemical Name:4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one
CAS No.:1608117-72-1
Molecular Formula:C₃₄H₃₄N₂O₃S
Molecular Weight:550.722
Hs Code.:

Synonyms:4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

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Chemical Property of 4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

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Technology Process of 4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

There total 3 articles about 4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 624-31-7
4-tolyl iodide

: 1608117-71-0
N-benzyl-N-(4-methylpenta-2,3-dienyl)-2-(4-methylphenylsulfonamido)benzamide

: 1608117-72-1
4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

Guidance literature:: N-benzyl-N-(4-methylpenta-2,3-dienyl)-2-(4-methylphenylsulfonamido)benzamide; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 50 ℃; for 0.166667h; Inert atmosphere;

4-tolyl iodide; With dichloro bis(acetonitrile) palladium(II); n-butyllithium; tetrabutylammomium bromide; In hexane; dimethyl sulfoxide; mineral oil; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.jorganchem.2013.11.010

Reference yield:

: 6311-23-5
2-(toluene-4-sulfonylamino)-benzoic acid

: 1608117-72-1
4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; dmap / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.17 h / 50 °C / Inert atmosphere

2.2: 2 h / 90 °C / Inert atmosphere

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;
DOI:10.1016/j.jorganchem.2013.11.010

Reference yield:

: N-benzyl-(4-methylpenta-2,3-dienyl)-amine

: 1608117-72-1
4-benzyl-2-(2-methyl-1-p-tolylprop-1-enyl)-1-tosyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; dmap / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.17 h / 50 °C / Inert atmosphere

2.2: 2 h / 90 °C / Inert atmosphere

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;
DOI:10.1016/j.jorganchem.2013.11.010