{2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester
CAS No.:204196-34-9
Molecular Formula:C₄₀H₄₈F₄N₄O₃
Molecular Weight:708.84
Hs Code.:

{2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Synonyms:{2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

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Chemical Property of {2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

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Technology Process of {2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

There total 8 articles about {2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 204196-32-7
(3-Hydroxy-propyl)-[2-((3-methyl-benzyl)-{6-[(3-trifluoromethyl-benzylamino)-methyl]-pyridin-2-ylmethyl}-amino)-ethyl]-carbamic acid tert-butyl ester

: 204196-34-9
{2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; Ambient temperature;
DOI:10.1021/jm970598u

Reference yield:

: 620-13-3
1-bromomethyl-3-methyl-benzene

: 204196-34-9
{2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / K₂CO₃ / acetonitrile / Ambient temperature

2: 42 percent / hydrazine / CH₂Cl₂ / 2 h / Ambient temperature

3: 63 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 80 percent / K₂CO₃ / acetonitrile / Ambient temperature

5: 82 percent / PhSH, K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

6: 98 percent / K₂CO₃ / acetonitrile / Ambient temperature

With potassium carbonate; thiophenol; triethylamine; hydrazine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970598u

Reference yield:

: 192379-49-0
{2-[[6-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-pyridin-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

: 204196-34-9
{2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / PhSH, K₂CO₃ / dimethylformamide / 4 h / Ambient temperature

2: 91 percent / K₂CO₃ / acetonitrile / Ambient temperature

3: 42 percent / hydrazine / CH₂Cl₂ / 2 h / Ambient temperature

4: 63 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 80 percent / K₂CO₃ / acetonitrile / Ambient temperature

6: 82 percent / PhSH, K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

7: 98 percent / K₂CO₃ / acetonitrile / Ambient temperature

With potassium carbonate; thiophenol; triethylamine; hydrazine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970598u