2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile

Base Information

• Chemical Name: 2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile
• CAS No.: 416860-94-1
• Molecular Formula: C₂₁H₂₂N₂O
• Molecular Weight: 318.418
• Mol file: 416860-94-1.mol

Synonyms:2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile

Chemical Property of 2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile

There total 1 articles about 2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]acetonitrile (416860-87-2) + methyl iodide (74-88-4) → 2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile (416860-94-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4.5h;

DOI:10.1248/cpb.50.31

Reference yield: 95.0%

2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile (416860-94-1) → 2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionamine (416860-95-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; benzene; for 1.5h; Heating;

DOI:10.1248/cpb.50.31

Reference yield:

2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionitrile (416860-94-1) → N-[2-(5-methoxy-1-phenethyl-1H-indol-3-yl)-2-methyl-propyl]-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / LiAlH₄ / benzene; diethyl ether / 1.5 h / Heating

2: 45 percent / Et₃N / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane; benzene;

DOI:10.1248/cpb.50.31

upstream raw materials:

[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]acetonitrile

methyl iodide

Downstream raw materials:

2-[5-methoxy-1-(2-phenethyl)-1H-indol-3-yl]-2-methylpropionamine