ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

Base Information

Chemical Name:ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate
CAS No.:184879-53-6
Molecular Formula:C₂₃H₂₇ClO₃
Molecular Weight:386.919
Hs Code.:

Synonyms:ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

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Chemical Property of ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

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Technology Process of ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

There total 6 articles about ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 184879-54-7
ethyl 2-(5-chloroinden-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

: 184879-53-6
ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; for 3h; under 760 Torr;
DOI:10.1021/jm950364f

Reference yield:

: 42348-86-7
5-chloro-1-indanone

: 184879-53-6
ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-isopropylcyclohexylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, from -70 deg C to RT, overnight

2: 66 percent / 12N aq. HCl / ethanol / 0.5 h / Heating

3: 65 percent / H₂, AcOH / 5percent Pd/C / 3 h / 760 Torr

With hydrogenchloride; n-butyllithium; N-cyclohexylisopropylamine; hydrogen; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm950364f

Reference yield:

: 99-89-8
4-Isopropylphenol

: 184879-53-6
ethyl 2-(5-chloroindan-1-yl)-2-(4-isopropylphenoxy)-2-methylacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 70 °C

2: 1.) N-isopropylcyclohexylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, from -70 deg C to RT, overnight

3: 66 percent / 12N aq. HCl / ethanol / 0.5 h / Heating

4: 65 percent / H₂, AcOH / 5percent Pd/C / 3 h / 760 Torr

With hydrogenchloride; n-butyllithium; N-cyclohexylisopropylamine; hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950364f