42348-86-7 Usage
Chemical Properties
White Crystal
Uses
Different sources of media describe the Uses of 42348-86-7 differently. You can refer to the following data:
1. 5-Chloro-1-indanone is the important intermediate of du pont company's new varieties of pesticides indoxacarb (popular name: indoxacarb), is also a kind of important medicine intermediate simultaneously.
5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types.
5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors.
2. 5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may also be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors. It participates in the Irie?s synthesis of substituted pyridines.
3. 5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors.
Preparation
3-chlorobenzaldehyde as raw material first reacts with propionic acid to prepare 3-chloro-phenylpropionic acid, which is then subjected to Friedel-Crafts acylation reaction to prepare 5-chloro-1-indanone. Organic solvents of formic acid diethylamine participate in the first step, and the reaction temperature is 20-150℃. An organic solvent of methylene chloride and a catalyst of zinc chloride participate in the second step, and the reaction temperature is -10 to 80 ℃.
Synthetic method of 5-chloro-1-indanone
General Description
5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types.
Check Digit Verification of cas no
The CAS Registry Mumber 42348-86-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,3,4 and 8 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 42348-86:
(7*4)+(6*2)+(5*3)+(4*4)+(3*8)+(2*8)+(1*6)=117
117 % 10 = 7
So 42348-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H7ClO/c10-7-2-3-8-6(5-7)1-4-9(8)11/h2-3,5H,1,4H2
42348-86-7Relevant articles and documents
Synthesis method of 5-chloro-1-indanone
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Paragraph 0025-0044, (2021/07/10)
The invention relates to a synthesis method of 5-chloro-1-indanone, and belongs to the technical field of organic synthesis. According to the invention, 1-(4-chlorphenyl)-2-propylene-1-ketone is used as a raw material, and under the catalysis of hydrogen chloride, intramolecular cyclization is carried out to generate 5-chloro-1-indanone. The hydrogen chloride gas is used for replacing aluminum trichloride catalysis in a traditional process, the low-temperature process is used for replacing the high-temperature process, the risk that aluminum trichloride possibly explodes when encountering water under the high-temperature condition is avoided, and essential safety of the process is achieved. Besides, the synthesis method only generates a small amount of acid-base neutralization wastewater, so that the environmental protection benefit is greatly improved.
Preparation method of 5-chloro-1-indanone
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Paragraph 0007; 0037-0050, (2021/03/11)
The invention provides a preparation method of 5-chloro-1-indanone, and belongs to the technical field of organic synthesis. Chlorobenzene and 3-chloropropionyl chloride are used as raw materials, mixed molten salt and heteropolyacid are used as catalysts, and heating reaction is performed to obtain 5-chloro-1-ndanone, wherein the heteropolyacid is SiO2 loaded phosphotungstic acid, and the mixed molten salt is a mixture of any two or three of potassium chloride, sodium chloride and aluminum chloride. By controlling the feeding temperature and the feeding sequence, the reaction is carried out at a lower temperature, the problems of large solid amount, high temperature, violent reaction, large tar amount, carbonization of raw materials, more three wastes and the like when aluminum trichloride is used as a catalyst are avoided, and the yield of 5-chloro-1-indanone can reach up to 85%.
Synthesis process of indoxacarb
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Paragraph 0015-0017, (2020/05/30)
The invention discloses a synthesis process of indoxacarb. The method comprises the following steps: reacting m-chlorobenzaldehyde serving as a raw material with malonic acid to remove monomolecular water and carbon dioxide to generate an intermediate SRCA, performing a hydrogenation reduction on the intermediate SRCA in an autoclave in the presence of a catalyst to obtain an intermediate SRCH, and cyclizing the SRCH by using hydrogen fluoride as a dehydrating agent to obtain the final product indoxacarb. The synthesis process is simple and easy to implement, energy is saved, consumption is reduced, the yield is increased, and good economic and environmental benefits are obtained.
