Ethyl 6-bromo-1H-indazole-3-carboxylate

Base Information

• Chemical Name: Ethyl 6-bromo-1H-indazole-3-carboxylate
• CAS No.: 885272-94-6
• Molecular Formula: C₁₀H₉BrN₂O₂
• Molecular Weight: 269.098
• Hs Code.: 2933990090
• Mol file: 885272-94-6.mol

Synonyms:6-Bromo-1H-indazole-3-carboxylic acid ethyl ester;Ethyl-6-brom-1H-indazol-3-carboxylat;

Chemical Property of Ethyl 6-bromo-1H-indazole-3-carboxylate

Chemical Property:

• Vapor Pressure: 8.15E-07mmHg at 25°C
• Refractive Index: 1.653
• Boiling Point: 406.4 °C at 760 mmHg
• Flash Point: 199.6 °C
• PSA: 54.98000
• Density: 1.624 g/cm³
• LogP: 2.50210
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-1H-indazole-3-carboxylic acid ethyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 6-bromo-1H-indazole-3-carboxylate

There total 3 articles about Ethyl 6-bromo-1H-indazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

6-bromo-1H-indazole-3-carboxylic acid (660823-36-9) → ethyl 6-bromo-1H-indazole-3-carboxylate (885272-94-6)

Guidance literature:

With thionyl chloride; In ethanol; for 3h; Reflux;

Reference yield:

6-bromo-1H-indazole-3-carboxylic acid (660823-36-9) + ethanol (64-17-5) → ethyl 6-bromo-1H-indazole-3-carboxylate (885272-94-6)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

Reference yield:

6-bromoisatin (6326-79-0) → ethyl 6-bromo-1H-indazole-3-carboxylate (885272-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 1 h / 50 °C

1.2: 0.5 h / 0 °C

1.3: 1 h

2.1: thionyl chloride / 3 h / Reflux

With thionyl chloride; sodium hydroxide; In water;

upstream raw materials:

6-bromo-1H-indazole-3-carboxylic acid

ethanol

6-bromoisatin

Downstream raw materials:

1-tert-butyl 3-ethyl-6-(4-nitrophenyl)-1H-indazole-1,3-dicarboxylate

ethyl 6-(4-aminophenyl)-1H-indazole-3-carboxylate

ethyl 6-(4-(3-(trifluoromethyl)benzamido)phenyl)-1H-indazole-3-carboxylate

ethyl 6-(4-(3-(3,4-dichlorophenyl)ureido)phenyl)-1H-indazole-3-carboxylate

Refernces

• 1、 -. "SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK". Page/Page column 248. . Retrieved 2017/08/07.
• 2、 -. "NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT". Page/Page column 17. . Retrieved 2010/06/20.