5>enkephalin trifluoroacetate

Base Information

Chemical Name:5>enkephalin trifluoroacetate
CAS No.:107959-99-9
Molecular Formula:C₂HF₃O₂*C₃₆H₄₉N₅O₇
Molecular Weight:777.838
Hs Code.:

<N,N-bis(cyclopropylmethyl),Leu<sup>5</sup>>enkephalin trifluoroacetate

Synonyms:5>enkephalin trifluoroacetate

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Chemical Property of 5>enkephalin trifluoroacetate

Chemical Property:

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Technology Process of 5>enkephalin trifluoroacetate

There total 10 articles about 5>enkephalin trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

: 107960-00-9
N,N-bis(cyclopropylmethyl)-O-tert-butyltyrosylglycylglycylphenylalanylleucine tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 107959-99-9
5>enkephalin trifluoroacetate

Guidance literature:: With methoxybenzene; In dichloromethane; at 25 ℃; for 3.25h;
DOI:10.1021/jm00390a005

Reference yield:

: 5545-54-0
N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

: 107959-99-9
5>enkephalin trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF

2: 86.5 percent / ammonium formate, H₂ / 10percent Pd/C / methanol / 0.67 h

3: 89.7 percent / N,N-diisopropylethylamine / toluene / 2.25 h / Heating

4: 85.9 percent / 0.25 N NaOH / tetrahydrofuran / 25 °C

5: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 to -20 deg C, 1 h, 2.) THF, DMF, 25 deg C, 1 h

6: 88.3 percent / anisole / CH₂Cl₂ / 3.25 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; ammonium formate; methoxybenzene; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00390a005

Reference yield:

: 16679-94-0
N-[(phenylmethoxy)carbonyl]-L-tyrosine

: 107959-99-9
5>enkephalin trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: conc. H₂SO₄ / CH₂Cl₂

2: 89.7 percent / 0.25 N NaOH / tetrahydrofuran / 25 °C

3: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF

4: 86.5 percent / ammonium formate, H₂ / 10percent Pd/C / methanol / 0.67 h

5: 89.7 percent / N,N-diisopropylethylamine / toluene / 2.25 h / Heating

6: 85.9 percent / 0.25 N NaOH / tetrahydrofuran / 25 °C

7: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 to -20 deg C, 1 h, 2.) THF, DMF, 25 deg C, 1 h

8: 88.3 percent / anisole / CH₂Cl₂ / 3.25 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; sulfuric acid; hydrogen; ammonium formate; methoxybenzene; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00390a005