5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one

Base Information

Chemical Name:5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one
CAS No.:81389-16-4
Molecular Formula:C₁₆H₁₁Cl₂NO₂
Molecular Weight:320.175
Hs Code.:

Synonyms:5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one

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Chemical Property of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one

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Technology Process of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one

There total 6 articles about 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 81389-15-3
8-chloro-9b-(2-chlorophenyl)-3,4-dihydro-9aH-oxazirino<3,2-a><2>benzazepin-5-(5H)-one

: 81389-16-4
5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 0.166667h; Ambient temperature;
DOI:10.1021/jo00133a040

Reference yield:

: 76049-64-4
3-amino-1-[2-(2-chlorobenzoyl)-4-chlorophenyl]-propyne

: 81389-16-4
5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / mercuric sulfate, formic acid / CH₂Cl₂ / 2 h / 0 °C

2: 0.9 g / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

3: 60 percent / 3 N aq. sodium hydroxide / tetrahydrofuran / 0.17 h / Ambient temperature

With sodium hydroxide; formic acid; mercury(II) sulfate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00133a040

Reference yield:

: 76049-54-2
N-<<4-chloro-2-(2-chlorobenzoyl)phenyl>-3-propynyl>isoindole-1,3(2H)-dione

: 81389-16-4
5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-hydroxyazirino<1,2-b>isoquinolin-8(8aH)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / 40percent aq. methylamine / aq. ethanol / 2 h / Ambient temperature

2: 62 percent / mercuric sulfate, formic acid / CH₂Cl₂ / 2 h / 0 °C

3: 0.9 g / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

4: 60 percent / 3 N aq. sodium hydroxide / tetrahydrofuran / 0.17 h / Ambient temperature

With sodium hydroxide; formic acid; mercury(II) sulfate; 3-chloro-benzenecarboperoxoic acid; methylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00133a040