tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate
CAS No.:1073153-79-3
Molecular Formula:C₁₉H₂₄FNO₄
Molecular Weight:349.402
Hs Code.:

Synonyms:tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 403-42-9
1-(4-fluorophenyl)ethanone

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1073153-79-3
tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate

Guidance literature:: 1-(4-fluorophenyl)ethanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

: 914654-75-4
1-(1,1-dimethylethyl) 4-piperidinedicarboxylate anhydride with 1H-imidazole-1-carboxylic acid

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1073153-79-3
tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2008.07.079

Reference yield: 30.0%

: 1073153-79-3
tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate

: 1073153-81-7
C₁₉H₂₃FN₂O₃

: 1073153-82-8
C₁₉H₂₃FN₂O₃

Guidance literature:: tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropanoyl)piperidine-1-carboxylate; With hydroxylamine; In dichloromethane; at 20 ℃;

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/j.bmcl.2008.07.079