[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

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Chemical Name:[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
CAS No.:222556-26-5
Molecular Formula:C₃₁H₃₄N₂O₆
Molecular Weight:530.621
Hs Code.:

Synonyms:[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

There total 5 articles about [(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 222556-25-4
(S)-3-[(S)-2-Azido-3-(3-benzyloxy-phenyl)-propionyl]-4-benzyl-oxazolidin-2-one

: 222556-26-5
[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on barium sulfate; In ethyl acetate;
DOI:10.1016/S0040-4039(99)00212-9

Reference yield:

: 621-54-5
3-(3-hydroxyphenyl)-propanoic acid

: 222556-26-5
[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 71 percent / K₂CO₃; NaOH / 60 °C

2.1: 82 percent / PivCl; Et₃N / tetrahydrofuran / -78 °C

3.1: KHMDS; trisyl azide / tetrahydrofuran / -78 °C

3.2: 59 percent / trisyl azide / acetic acid / 20 °C

4.1: 100 percent / H₂ / Pd-BaSO₄ / ethyl acetate

With sodium hydroxide; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; potassium carbonate; triethylamine; palladium on barium sulfate; In tetrahydrofuran; ethyl acetate; 1.1: Etherification / 2.1: Condensation / 3.1: Substitution / 3.2: Hydrolysis / 4.1: Catalytic hydrogenation;
DOI:10.1016/S0040-4039(99)00212-9

Reference yield:

: 14755-02-3,588-30-7
3-hydroxy-trans-cinnamic acid

: 222556-26-5
[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂ / Pd/C / ethyl acetate / 20 °C

2.1: 71 percent / K₂CO₃; NaOH / 60 °C

3.1: 82 percent / PivCl; Et₃N / tetrahydrofuran / -78 °C

4.1: KHMDS; trisyl azide / tetrahydrofuran / -78 °C

4.2: 59 percent / trisyl azide / acetic acid / 20 °C

5.1: 100 percent / H₂ / Pd-BaSO₄ / ethyl acetate

With sodium hydroxide; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; potassium carbonate; triethylamine; palladium on activated charcoal; palladium on barium sulfate; In tetrahydrofuran; ethyl acetate; 1.1: Hydrogenation / 2.1: Etherification / 3.1: Condensation / 4.1: Substitution / 4.2: Hydrolysis / 5.1: Catalytic hydrogenation;
DOI:10.1016/S0040-4039(99)00212-9