C₃₄H₅₀N₂OSi

Base Information

• Chemical Name: C₃₄H₅₀N₂OSi
• CAS No.: 1402829-76-8
• Molecular Formula: C₃₄H₅₀N₂OSi
• Molecular Weight: 530.869
• Mol file: 1402829-76-8.mol

Synonyms:C₃₄H₅₀N₂OSi

Chemical Property of C₃₄H₅₀N₂OSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₅₀N₂OSi

There total 5 articles about C₃₄H₅₀N₂OSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(2R,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile (1026449-62-6) + isobutylamine (78-81-9) → C34H50N2OSi (1402829-76-8)

Guidance literature:

(2R,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile; With diisobutylaluminium hydride; In diethyl ether; hexane; at -78 ℃; for 3h;

isobutylamine; With ammonium bromide; In methanol; diethyl ether; hexane; at 20 ℃; for 3h;

With sodium tetrahydroborate; In methanol; diethyl ether; hexane; at 20 ℃; Cooling with ice;

DOI:10.1002/cmdc.201200271

Reference yield:

(2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanenitrile (118970-36-8) → C34H50N2OSi (1402829-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C

2.1: diisobutylaluminium hydride / diethyl ether; hexane / 3 h / -78 °C

2.2: 3 h / 20 °C

2.3: 20 °C / Cooling with ice

With 1H-imidazole; diisobutylaluminium hydride; In diethyl ether; hexane; dichloromethane;

DOI:10.1002/cmdc.201200271

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → C34H50N2OSi (1402829-76-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide; potassium carbonate / water / 3 h / Reflux

2.1: lithium aluminium tetrahydride / diethyl ether / 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 0 °C

3.2: 1 h

4.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / -20 °C

5.1: 1H-imidazole / dichloromethane / 0 - 20 °C

6.1: diisobutylaluminium hydride / diethyl ether; hexane / 3 h / -78 °C

6.2: 3 h / 20 °C

6.3: 20 °C / Cooling with ice

With 1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; sodium hydroxide; In diethyl ether; hexane; dichloromethane; water; 3.1: |Swern Oxidation;

DOI:10.1002/cmdc.201200271

upstream raw materials:

benzyl bromide

(2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanenitrile

(2R,3S)-2-(tert-butyldimethylsilyloxy)-3-(dibenzylamino)-4-phenylbutanenitrile

isobutylamine

Downstream raw materials:

(2S,3S)-3-(dibenzylamino)-1-(isobutylamino)-4-phenylbutan-2-ol

N-((2S,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide

N-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide