ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate

Base Information

• Chemical Name: ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate
• CAS No.: 259816-73-4
• Molecular Formula: C₂₅H₂₂N₂O₂
• Molecular Weight: 382.462
• Mol file: 259816-73-4.mol

Synonyms:ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate

Chemical Property of ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate

There total 2 articles about ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

biphenyl-4-methylchloride (1667-11-4) + ethyl 4-(4-pyridinyl)pyrrole-3-carboxylate (197774-66-6) → ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate (259816-73-4)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; at 20 ℃; for 15h;

Reference yield:

ethyl 3-(4-pyridinyl)-(2E)-propenoate (123293-78-7) → ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate (259816-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / NaH / dimethylsulfoxide; diethyl ether / 0.25 h / 20 °C

2: 67 percent / tetrabutylammonium hydrogen sulfate; NaOH / CH₂Cl₂; H₂O / 15 h / 20 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; In diethyl ether; dichloromethane; water; dimethyl sulfoxide;

Reference yield: 90.0%

ethyl 1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylate (259816-73-4) → (1-biphenyl-4-ylmethyl-4-pyridin-4-yl-1H-pyrrol-3-yl)-methanol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1.5h;

upstream raw materials:

biphenyl-4-methylchloride

ethyl 4-(4-pyridinyl)pyrrole-3-carboxylate

ethyl 3-(4-pyridinyl)-(2E)-propenoate

Downstream raw materials:

1-(4-biphenylmethyl)-4-(4-pyridinyl)pyrrole-3-carboxylic acid

(1-biphenyl-4-ylmethyl-4-pyridin-4-yl-1H-pyrrol-3-yl)-imidazol-1-yl-methanone