4-AMINO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-AMINO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 885272-42-4
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.298
• Hs Code.: 2933990090
• Mol file: 885272-42-4.mol

Synonyms:4-AMINO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property of 4-AMINO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 370.4±41.0 °C(Predicted)
• PKA: 4.19±0.20(Predicted)
• PSA: 55.56000
• Density: 1.177±0.06 g/cm3(Predicted)
• LogP: 3.21260
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2,3-dihydro-indole-1-carboxylicacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 4-AMINO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 4-nitro-1H-indole-1-carboxylate (913836-24-5) → tert-butyl 4-amino-1H-indole-1-carboxylate (885270-30-4) + C13H18N2O2 (885272-42-4)

Guidance literature:

With hydrogen; 5% Pd(II)/C(eggshell); In toluene; at 20 ℃; for 3h; under 2585.81 Torr;

Reference yield:

tert-butyl 4-nitro-1H-indole-1-carboxylate (913836-24-5) → C13H18N2O2 (885272-42-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 60 ℃; for 10h;

DOI:10.1021/acs.jmedchem.0c01116

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → C13H18N2O2 (885272-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: hydrogen; palladium on activated charcoal / methanol / 10 h / 60 °C

With palladium on activated charcoal; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.0c01116

upstream raw materials:

tert-butyl 4-nitro-1H-indole-1-carboxylate

di-tert-butyl dicarbonate

4-nitro-1H-indoIe

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