Technology Process of 4-Methoxy-8-tosyloxy-β-carboline
There total 6 articles about 4-Methoxy-8-tosyloxy-β-carboline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,2-dimethoxy-propane; 2-Formyl-4-oxo-8-tosyloxy-1,2,3,4-tetrahydro-β-carboline;
With
toluene-4-sulfonic acid;
In
benzene;
at 20 ℃;
for 0.5h;
With
chloranil;
In
benzene;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 100 percent / DIBAL-H / CH2Cl2 / 0.08 h / -78 °C
2.1: 89 percent / MnO2 / CH2Cl2 / 3 h / 20 °C
3.1: 79 percent / Et3N; NaBH3CN / methanol / 24 h / 20 °C
4.1: 100 percent / HCOOH / 24 h / 20 °C
5.1: 80 percent / MsOH / 8 h / 55 °C
6.1: p-TsOH / benzene / 0.5 h / 20 °C
6.2: 70 percent / chloranil / benzene / 12 h / 20 °C
With
manganese(IV) oxide; formic acid; methanesulfonic acid; diisobutylaluminium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; triethylamine;
In
methanol; dichloromethane; benzene;
1.1: Reduction / 2.1: Oxidation / 3.1: Condensation / 4.1: Formylation / 5.1: Cyclization / 6.1: Substitution / 6.2: Oxidation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 79 percent / Et3N; NaBH3CN / methanol / 24 h / 20 °C
2.1: 100 percent / HCOOH / 24 h / 20 °C
3.1: 80 percent / MsOH / 8 h / 55 °C
4.1: p-TsOH / benzene / 0.5 h / 20 °C
4.2: 70 percent / chloranil / benzene / 12 h / 20 °C
With
formic acid; methanesulfonic acid; sodium cyanoborohydride; toluene-4-sulfonic acid; triethylamine;
In
methanol; benzene;
1.1: Condensation / 2.1: Formylation / 3.1: Cyclization / 4.1: Substitution / 4.2: Oxidation;
