4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2)

Base Information

• Chemical Name: 4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2)
• CAS No.: 644982-34-3
• Molecular Formula: C₂₇H₃₃Br₂FN₂O₃
• Molecular Weight: 612.377
• Mol file: 644982-34-3.mol

Synonyms:4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2)

Chemical Property of 4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2)

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2)

There total 1 articles about 4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid (644981-80-6) + [1-(3,5-dibromo-phenyl)-ethyl]-methylamine (enantiomer 2) → 4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2) (644982-34-3)

Guidance literature:

[1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 0.5h;

[1-(3,5-dibromo-phenyl)-ethyl]-methylamine (enantiomer 2); In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

4-({[1-(3,5-dibromo-phenyl)-ethyl]-methyl-carbamoyl}-methyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (enantiomer 2) (644982-34-3) → N-[1-(3,5-dibromo-phenyl)-ethyl]-2-[4-(4-fluoro-phenyl)-piperidin-4-yl]-N-methyl acetamide (enantiomer 2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

upstream raw materials:

[1-{[(1,1-dimethylethyl)-oxy]-carbonyl}-4-(4-fluorophenyl)-4-piperidinyl]-acetic acid