cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide

Base Information

Chemical Name:cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide
CAS No.:138335-56-5
Molecular Formula:C₂₄H₃₀F₃N₂O₂*I
Molecular Weight:562.414
Hs Code.:

Synonyms:cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide

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Chemical Property of cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide

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Technology Process of cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide

There total 7 articles about cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 138335-21-4
(3S,4S)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

: 74-88-4
methyl iodide

: 138335-56-5
cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide

Guidance literature:: In tetrahydrofuran; for 2.5h; Ambient temperature;
DOI:10.1021/jm00082a020

Reference yield:

: 6656-49-1
2-methyl-1-nitro-3-(trifluoromethyl)benzene

: 138335-56-5
cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / dimethylformamide / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

3: H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

4: MeONa / methanol / 3 h / Heating

5: LiBr / dimethylformamide / 4 h / Heating

6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, toluene, heating, 2 h

7: 84 percent / tetrahydrofuran / 2.5 h / Ambient temperature

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020

Reference yield:

: 7443-25-6
dimethyl 2-(4-methoxybenzylidene)malonate

: 138335-56-5
cis-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-1-<2-(trimethylammonio)ethyl>-2H-1-benzazepin-2-one, iodide

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / dimethylformamide / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

3: H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

4: MeONa / methanol / 3 h / Heating

5: LiBr / dimethylformamide / 4 h / Heating

6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, toluene, heating, 2 h

7: 84 percent / tetrahydrofuran / 2.5 h / Ambient temperature

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020