allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate

Base Information

Chemical Name:allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate
CAS No.:1307272-96-3
Molecular Formula:C₂₁H₂₀ClFN₄O₃S
Molecular Weight:462.932
Hs Code.:

Synonyms:allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate

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Chemical Property of allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate

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Technology Process of allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate

There total 1 articles about allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1195769-50-6
3-hydroxy-2,2-dimethylpropanethioamide

: 1195769-52-8
2-propen-1-yl {3-[bromo(2-chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}carbamate

: 1307272-96-3
allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate

Guidance literature:: In ISOPROPYLAMIDE; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 45.8%

: 1307272-96-3
allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate

: 1331843-25-4
2-(4-(3-amino-2-fluorophenyl)-5-(2-chloropyrimidin-4-yl)thiazol-2-yl)-2-methylpropan-1-ol

Guidance literature:: With tri-n-butyl-tin hydride; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; at 40 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1307272-96-3
allyl 3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenylcarbamate

: 1307272-97-4
N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tri-n-butyl-tin hydride; acetic acid / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 4 h / 40 °C / Inert atmosphere

2: pyridine / 2 h / 20 °C / Inert atmosphere

With pyridine; tri-n-butyl-tin hydride; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane;