N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

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Chemical Name:N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate
CAS No.:1410809-43-6
Molecular Formula:C₂HF₃O₂*C₂₁H₂₅N₃O₄
Molecular Weight:497.471
Hs Code.:

N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Synonyms:N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

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Chemical Property of N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

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Technology Process of N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

There total 5 articles about N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1410809-35-6
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

: 1410809-43-6
N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Guidance literature:: formaldehyd; N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate; With triethylamine; In N,N-dimethyl-formamide; for 3h;

With sodium cyanoborohydride; acetic acid; N-butylamine; at 0 - 20 ℃;

Reference yield:

: 13949-93-4,13950-12-4,77183-91-6,77183-92-7,109716-50-9,109716-61-2,20417-61-2
ethyl-2-formyl-1-cyclopropane carboxylate

: 1410809-43-6
N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; methanol / 18 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

3.1: N-butylamine / hydroxylamine hydrochloride; copper(l) chloride / tetrahydrofuran; methanol / 4 h / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.33 h

4.2: 48 h

5.1: triethylamine / N,N-dimethyl-formamide / 3 h

5.2: 0 - 20 °C

With methanol; lithium aluminium tetrahydride; potassium carbonate; N-butylamine; triethylamine; trifluoroacetic acid; hydroxylamine hydrochloride; copper(l) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 144478-66-0
(2-ethynylcyclopropyl)methanol

: 1410809-43-6
N-((S)-1-(hydroxyamino)-3-methyl-3-(methylamino)-1-oxobutan-2-yl)-4-(((1,2-trans)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-butylamine / hydroxylamine hydrochloride; copper(l) chloride / tetrahydrofuran; methanol / 4 h / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.33 h

2.2: 48 h

3.1: triethylamine / N,N-dimethyl-formamide / 3 h

3.2: 0 - 20 °C

With N-butylamine; triethylamine; trifluoroacetic acid; hydroxylamine hydrochloride; copper(l) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;