1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone

Base Information

Chemical Name:1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone
CAS No.:1427161-66-7
Molecular Formula:C₁₉H₁₆N₄O₂S
Molecular Weight:364.428
Hs Code.:

Synonyms:1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone

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Technology Process of 1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone

There total 2 articles about 1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 75717-53-2
2-chloro-1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

: 6868-28-6
2-((1H-indol-3-yl)methylene)hydrazine-1-carbothioamide

: 1427161-66-7
1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone

Guidance literature:: With pyridine; In ethanol; for 4h; Reflux;
DOI:10.1016/j.bmcl.2013.01.039

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1427161-66-7
1H-indole-3-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 4 h / Reflux

2: pyridine / ethanol / 4 h / Reflux

With pyridine; In ethanol; 2: |Hantzsch Thiazole Synthesis;
DOI:10.1016/j.bmcl.2013.01.039